藥效學(xué)研究是對(duì)藥物進(jìn)行有效性評(píng)價(jià)，目的在于闡明藥物防治和診斷疾病的機(jī)理，為開發(fā)和評(píng)價(jià)藥物提供科學(xué)依據(jù)。

藥效學(xué)研究的給藥方法：預(yù)防性給藥、治療性給藥、防治結(jié)合的給藥方式 選用一種以上動(dòng)物進(jìn)行藥效試驗(yàn)，每一方面藥理作用要選用2~3種動(dòng)物模型或者細(xì)胞模型來做。

Droxytryptamine (5-HT; serotonin) 5-HT3 receptor is an excitatory ligandgated ion channel expressed in for example the brain and the gastrointestinal tract. CSTI-300 as a selective, high affinity 5-HT3 receptor partial agonist. CSTI-300 was examined alongside the selective 5-HT3 receptor antagonist alosetron (which is also currently marketed as a therapeutic for IBS-d). Sub-cutaneous application of 5-hydroxytryptophan (5-HTP; 10 mg/kg) markedly increased the rat’s sensitivity to abdominal contractions. CSTI-300 and Alosetron displayed similar efficacy in a rodent in vivo model of IBS-d, measured by a reduction in colonic sensitivity. The experiments (Rat colon distension model of IBS-d) were carried out by Medicilon. The protocol complied with and was approved by the Institutional Animal Care and Use Committee and Medicilon is accredited by the NIH Office of laboratory Animal Welfare (OLAW) and AAALAC. Experiments (dog behavioural and emesis model) were performed by Medicilon. The protocol for the dog behavioural and emesis model complied with and was approved by the Institutional Animal Care and Use Committee.